In 2005, Washington landed his breakthrough role as Preston Burke on Grey's Anatomy. He also appeared in the films Love Jones (1997), Bulworth (1998), True Crime (1999), Romeo Must Die (2000), Exit Wounds (2001), Ghost Ship (2002), and Hollywood Homicide (2003). Washington began his career collaborating with director Spike Lee on the films Crooklyn (1994), Clockers (1995), Girl 6 (1996), and Get on the Bus (1996). Preston Burke in the first three seasons of the series Grey's Anatomy from 2005 to 2007. Following a series of film appearances, he came to prominence for portraying Dr. Isaiah Washington IV (born August 3, 1963) is an American actor and media personality.